Royal Epigen P5: epigenetic science from royal jelly

Although identical on a genetic level, worker bees and the queen bee differ in life span, fertility and size. The reason for these differences are epigenetic changes evoked by the feeding of royal jelly. Royal Epigen P5 isa peptide-based active ingredient that captures the epigenetic activity of royal jelly. Studies show that this new cosmetic ingredient- Activates the proteasomal system in skin cells. Stimulates skin regeneration and wound healing- Improves skin evenness for a youthful complexion

PhytoCellTec™ nunatak®, the latest stem cell active based on stem cells which come from the high alpine plant Saponaria pumila. This flower survived the last ice age by growing on ice-free mountain peaks, which are known as Nunataks. The distinctive survival characteristics of Saponaria pumila are still preservedin their stem cells and these are now available for skincare. PhytoCellTec™ nunatak®, has shown to efficiently protect dermal stem cells against UV-induced stress and to also maintain their stem cell activity.

Improving skin resilience with moss cell technology

About 470m years ago mosses were one of the first plants that moved out of the water and conquered the earth. Mosses possess no vertical roots and have a high surface area which makes it difficult for them to replenish lost water and nutrients from the soil. Therefore, mosses filter nutrients from the air and rain which makes them susceptible to the accumulation of pollutants such as heavy metals. In order to cope with the oxidative stress from pollution, mosses developed a particular anti-pollution matrix with a large set of antioxidants. The development of a specialized adaptation strategy was also needed for mosses to inhabit various climatic regions. They are masters in water retention, rehydration, fast recovery and cold resistance. It has recently been shown that mosses are even able to continue to grow after being frozen for 1,500 years in permafrost. The special mix of molecules that enables such resilience is of interest to the cosmetic industry.

MossCellTec – Biotechnology to grow moss sustainably in the lab

Although resilient, mosses grow slowly and are thus often under protection and cannot be harvested in the wild. Additionally, wild mosses filter the air and retain toxins that prevent their use in cosmetics. To make the adaptation skills of mosses available to cosmetics, a biotechnology to grow the plants in a laboratory setting was developed. A sterile protonema culture of the wild-type moss Physcomitrella patens in liquid culture was produced. Additionally, a new cold pressing extraction method was established to harvest all water soluble ingredients from the moss cells which were then sprayed on an isomalt matrix resulting in the active MossCellTec No.1. For the first time, moss cells that are biotechnologically produced in a clean and sustainable way can be used for cosmetics.

Stimulation of life extension factors: now for skin

Snow Algae Powder – a novel active based on unique extremophile algae - stimulates the life extension factor Klotho and activates AMPK, a master switch in the cellular defence system. In a clinical study using multiphoton tomography, Snow Algae Powder showed a clear improvement (+30,5%) of the papillary structure at the dermal epidermal junction – for a firmer and restructured skin. Its multi- dimensional anti-aging and repairing approach was also confirmed by proteomics technology. Moreover, in-vivo studies confirmed a visible improvement of the skin’s structure, tone and barrier function.